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After initial encoding, new information becomes fixed at a cellular level and integrated within networks of existing memories 1 , 2. This integration involves a reorganization of memory during which, with time, detailed, episodic memories are transformed into more semantic, gist-like representations 1 , 3. Although, the neural underpinnings of this time-dependent memory reorganization are at the heart of the neuroscience of memory, the neural evolution of memories over time remains a topic of much controversy.
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In particular, whether the hippocampus, a critical hub for initial memory formation 4 , 5 , 6 , 7 , 8 , is involved in remote memories or not has been controversial for decades 3 , 9 , 10 , 11 , The hippocampus can be subdivided into anterior and posterior parts—corresponding to the ventral and dorsal hippocampus, respectively, in rodents—and these parts differ in function, structure and their connections to cortical and subcortical areas 13 , 14 , A prominent proposal that was largely based on rodent data linked the ventral anterior hippocampus to emotion, stress, and affect, whereas the dorsal posterior hippocampus was implicated in cognitive functions such as learning, memory, and spatial navigation Electrophysiological and lesion studies in rodents, as well as human neuroimaging studies, however, suggest that this view may need to be revised and that both anterior and posterior hippocampal areas aHC and pHC, respectively may contribute to learning and memory processes, although the exact functional specialization is still unclear 14 , Air Faalconn Boy For Adorable Jordan Baby 6fWwdnqa , Further studies suggest that the aHC and pHC might be differentially involved in recent and remote memories 18 , 19 , 20 , yet whether the transformation of memory over time may be linked to time-dependent changes in aHC and pHC involvement in memory is completely unknown.
Here we determine whether there are time-dependent changes in aHC and pHC contributions to memory and if so, whether they are associated with the transformation from detailed to gist-like memory. To do so, we combined functional magnetic resonance imaging fMRI and multivariate representational similarity analysis RSA with a task probing memory transformation.
Participants learned 60 pictures of scenes and objects 30 neutral, 30 negative and performed a recognition test for these pictures in the MRI scanner either one day after encoding 1 d group or four weeks later 28 d group. Critically, the recognition test included, in addition to the old pictures learned during encoding and completely novel pictures, related lure pictures that carried the semantic gist of the old pictures but had different details Fig.
Task and behavioral results. This finding indicates a time-dependent memory transformation. At the neural level, this transformation was paralleled by a time-dependent decrease in the aHC, the hippocampal subregion that was directly linked to memory specificity. The pHC, in turn, was not related to memory specificity and did not decline over time. Further, RSA revealed that activity patterns in the aHC were highly specific and differed between old and new memories in the 1 d group but not after 28 d.
Representations in the pHC became more gist-like after 28 days. Together, these findings show that the aHC that supports memory specificity declines over time, whereas pHC remains stable over time but carries more gist-like representations. Our data suggest that the time-dependent transformation from detailed to gist-like memory is linked to a reorganization within the hippocampus. During encoding on experimental day 1, participants of the 1 d- and 28 d groups learned the pictures equally well Supplementary Fig.
This indicates that participants in the 28 d group particularly had difficulties differentiating between old pictures and related pictures carrying the gist of the old pictures, suggesting a transformation towards more gist-like memory. Additionally, participants were asked to rate their confidence on a 4-point-scale, whenever they indicated that they had seen the picture before Fig. We further analyzed the 60 matching picture pairs i.
To elucidate the neural underpinnings of the memory dynamics over time, we first analyzed time-dependent changes in the hippocampus as a whole and other cortical and subcortical areas that have been implicated in episodic memory before. We obtained overall reduced activity in the hippocampus, parahippocampus, and the amygdala in the 28 d group compared to 1 d group see Supplementary Fig.
In addition, we performed a psychophysiological interaction PPI analysis to test whether the cross-talk of the hippocampus with other areas critical for memory formation changed as a function of time. Our analysis showed specifically reduced functional connectivity between the right hippocampus and the right amygdala in the 28 d group compared to the 1 d group Supplementary Fig. This decrease in hippocampal-amygdala connectivity was of particular interest as the interaction of these areas is commonly linked to vivid memory As hippocampal involvement in remote memories has been argued to depend critically on memory vividness 3 , 20 , we further explicitly looked at activity for old items that were recognized with high confidence.